The timing of human adaptation from Neanderthal introgression
نویسندگان
چکیده
منابع مشابه
The Strength of Selection against Neanderthal Introgression
Hybridization between humans and Neanderthals has resulted in a low level of Neanderthal ancestry scattered across the genomes of many modern-day humans. After hybridization, on average, selection appears to have removed Neanderthal alleles from the human population. Quantifying the strength and causes of this selection against Neanderthal ancestry is key to understanding our relationship to Ne...
متن کاملThe Genetic Cost of Neanderthal Introgression.
Approximately 2-4% of genetic material in human populations outside Africa is derived from Neanderthals who interbred with anatomically modern humans. Recent studies have shown that this Neanderthal DNA is depleted around functional genomic regions; this has been suggested to be a consequence of harmful epistatic interactions between human and Neanderthal alleles. However, using published estim...
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15 صفحه اولAdaptation by introgression
Both selective and random processes can affect the outcome of natural hybridization. A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals the mosaic nature of introgression, which is probably caused by a combination of selection and demography.
متن کاملA deterministic model of admixture and genetic introgression: the case of Neanderthal and Cro-Magnon.
There is an ongoing debate in the field of human evolution about the possible contribution of Neanderthals to the modern human gene pool. To study how the Neanderthal private alleles may have spread over the genes of Homo sapiens, we propose a deterministic model based on recursive equations and ordinary differential equations. If the Neanderthal population was large compared to the Homo sapien...
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ژورنال
عنوان ژورنال: Genetics
سال: 2021
ISSN: 1943-2631
DOI: 10.1093/genetics/iyab052